Table 2.
IC50 values of different drug-sensitive and -resistant cell lines of Sanguinarine.
| Sanguinarine (log10 IC50, M) | Control drug (log10 IC50, M) | ||
|---|---|---|---|
| ABCB1 Expression: | Daunorubicin | ||
| 7q21 (Chromosomal | R-value | 0.063 | *0.597 |
| Locus of ABCB1 Gene) | P-value | 0.327 | *4.82 × 10−6 |
| ABCB1 Expression | R-value | 0.082 | *0.684 |
| (Microarray) | P-value | 0.271 | *1.57 × 10−8 |
| ABCB1 Expression | R-value | 0.076 | *0.579 |
| (RT-PCR) | P-value | 0.297 | *4.19 × 10−6 |
| Rhodamine 123 | R-value | 0.010 | *0.544 |
| Accumulation | P-value | 0.471 | *1.51 × 10−5 |
| ABCB5 Expression: | Maytansine | ||
| ABCB5 Expression | R-value | 0.069 | *0.454 |
| (Microarray) | P-value | 0.299 | *6.67 × 10−4 |
| ABCB5 Expression | R-value | −0.021 | *0.402 |
| (RT-PCR) | P-value | 0.436 | *0.0034 |
| ABCC1 Expression: | Vinblastine | ||
| DNA Gene | R-value | −0.040 | *0.429 |
| Copy Number | P-value | 0.383 | *0.001 |
| ABCC1 Expression | R-value | 0.114 | *0.398 |
| (Microarray) | P-value | 0.198 | *0.003 |
| ABCC1 Expression | R-value | 0.134 | 0.299 |
| (RT-PCR) | P-value | 0.181 | *0.036 |
| ABCG2 Expression: | Pancratistatin | ||
| ABCG2 Expression | R-value | 0.107 | *0.329 |
| (Microarray) | P-value | 0.211 | *0.006 |
| ABCG2 Expression | R-value | 0.048 | *0.346 |
| (Western Blot) | P-value | 0.358 | *0.004 |
| EGFR Expression: | Erlotinib | ||
| EGFR Gene | R-value | 0.049 | −0.245 |
| Copy Number | P-value | 0.354 | *0.029 |
| EGFR Expression | R-value | 0.144 | *-0.458 |
| (Microarray) | P-value | 0.135 | *1.15 × 10−4 |
| EGFR Expression | R-value | −0.175 | *0.409 |
| (RNAse Protection) | P-value | 0.094 | *7.08 × 10−4 |
| EGFR Expression | R-value | 0.016 | *-0.376 |
| (Protein Array) | P-value | 0.452 | *0.001 |
| TP53 Mutation: | 5-Fluorouracil | ||
| TP53 Mutation | R-value | −0.198 | *-0.502 |
| (cDNA Sequencing) | P-value | 0.068 | *3.50 × 10−5 |
| TP53 Function | R-value | −0.145 | *-0.436 |
| (Yeast Functional Assay) | P-value | 0.148 | *5.49 × 10−4 |
| pan-RAS Mutation: | Melphalan | ||
| H-,K-,N-RAS Mutation | R-value | 0.253 | *0.367 |
| P-value | 0.026 | *0.002 |
*
R > 0.3 (or R < −0.3) and P < 0.05.