Table 3.
Correlation of constitutive mRNA expression of genes identified by COMPARE analysis with log10IC50 values for sanguinarine of the NCI tumor cell lines.
| COMPARE coefficient | GenBank accession | Experimental ID | Gene symbol | Name | Function |
|---|---|---|---|---|---|
| 0.775 | D86964 | GC35690 | DOCK2 | Dedicator of cytokinesis 2 | Functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP |
| 0.769 | D89077 | GC33424 | SLA | Src-like-adaptor RNA | Negatively regulates T-cell receptor (TCR) signaling |
| 0.765 | AA133246 | GC36535 | LAIR2 | Leukocyte-associated immunoglobulin-like receptor 2 | It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1 |
| 0.76 | D14889 | GC33186 | RAB33A | RAB33A, member RAS oncogene family | It is GTP-binding protein and may be involved in vesicle transport |
| 0.759 | AB007918 | GC35631 | KIF21B | Kinesin family member 21B | Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching, and spine formation |
| 0.748 | D30758 | GC27814 | ACAP1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface |
| 0.718 | M37033 | GC28789 | CD53 | CD53 molecule | Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion |
| 0.715 | AB018254 | GC39476 | KBTBD11 | Kelch repeat and BTB (POZ) domain containing 11 | Unknown |
| 0.711 | U51127 | GC32375 | IRF5 | Interferon regulatory factor 5 | Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection |
| 0.71 | AF013249 | GC27873 | LAIR1 | Leukocyte-associated immunoglobulin-like receptor 1 | It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases |
| 0.709 | X93595 | GC27133 | KIR3DL1 | Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis |
| 0.699 | AJ243937 | GC29466 | GPSM3 | G-protein signaling modulator 3 | GTPase regulator activity and GDP-dissociation inhibitor activity |
| 0.699 | AJ008112 | GC27500 | FMNL1 | Formin-like 1 | May play a role in the control of cell motility and survival of macrophages |
| 0.696 | U63127 | GC31882 | PSD4 | Pleckstrin and Sec7 domain containing 4 | Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells |
| 0.695 | AF031824 | GC37973 | CST7 | Cystatin F (leukocystatin) | Inhibits papain and cathepsin L but with affinities lower than other cystatins |
| 0.694 | D87457 | GC38648 | ELMO1 | Engulfment and cell motility 1 | Required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 |
| 0.692 | L41268 | GC27284 | KIR2DL3 | Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3, and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis |
| 0.69 | Y00638 | GC30951 | PTPRC | Protein tyrosine phosphatase, receptor type, C | Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN |
| 0.685 | J04132 | GC27477 | CD247 | CD247 molecule | Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering |
| 0.685 | U73394 | GC28642 | KIR2DL4 | Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | Inhibits the activity of NK cells thus preventing cell lysis |
| −0.506 | N36926 | GC31915 | GNA11 | Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | Acts as an activator of phospholipase C |
| −0.487 | M22299 | GC37799 | PLS3 | Plastin 3 | May play a role in the regulation of bone development |
| −0.472 | AB011159 | GC36349 | NCKAP1 | NCK-associated protein 1 | Part of the WAVE complex that regulates lamellipodia formation |
| −0.45 | D84454 | GC37231 | SLC35A2 | Solute carrier family 35 (UDP-galactose transporter), member A2 | Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function |
| −0.449 | M35011 | GC34135 | ITGB5 | Integrin, beta 5 | Acts as a receptor for adenovirus type C |
| −0.435 | D10522 | GC35417 | MARCKS | Myristoylated alanine-rich protein kinase C substrate | This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein |
| −0.431 | AF102265 | GC29686 | PGM3 | Phosphoglucomutase 3 | Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P |
| −0.431 | AL050268 | GC37394 | RAB1A | RAB1A, member RAS oncogene family | RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion |
| −0.428 | L10284 | GC30552 | CANX | Calnexin | Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum |
| −0.422 | U57627 | GC37169 | OCRL | Oculocerebrorenal syndrome of Lowe | Membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes |
| −0.419 | S71018 | GC27825 | PPIC | Peptidylprolyl isomerase C (cyclophilin C) | It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides |
| −0.414 | AB007860 | GC29831 | ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | Modulates PXN recruitment to focal contacts and cell migration |
| −0.412 | AF089816 | GC38772 | GIPC1 | GIPC PDZ domain containing family, member 1 | May be involved in G protein-linked signaling |
| −0.412 | L13857 | GC36251 | SOS1 | Son of sevenless homolog 1 (Drosophila) | Promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF |
| −0.409 | AF019612 | GC34390 | MBTPS2 | Membrane-bound transcription factor peptidase, site 2 | Intramembrane proteolysis of sterol-regulatory element-binding proteins |
| −0.409 | AF035287 | GC38763 | NPTN | Neuroplastin | May play a role in synaptic plasticity |
| −0.409 | L10678 | GC29255 | PFN2 | Profilin 2 | Binds to actin and affects the structure of the cytoskeleton |
| −0.404 | AF017445 | GC28548 | TNNI3K | TNNI3 interacting kinase | May play a role in cardiac physiology |
| −0.403 | AL049943 | GC36426 | FAM98A | Family with sequence similarity 98, member A | Unknown |
| −0.402 | M36341 | GC26981 | ARF4 | ADP-ribosylation factor 4 | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase |