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. 2018 Mar 2;8:3933. doi: 10.1038/s41598-018-22194-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targeted assessment of selected treatment-induced transcriptional changes in abdominal subcutaneous adipose tissue. The heatmap plot shows per patient longitudinal treatment-induced gene expression changes [defined as log2(post treatment expression) - log2(pre-treatment expression)] for selected transcripts related to natriuretic peptide signaling, lipolytic pathway, oxidative pathway and adipokines in abdominal subcutaneous adipose tissue (n = 70 patients; grouped per treatment arm). Color in the heatmap reflects transcript change from baseline per subject. Blue: downregulated transcripts; yellow: upregulated transcripts. The adjacent table depicts the corresponding transcript ratio change from baseline (RC) and P-value per treatment arm.