Table 1.
Clinical characteristics of patients involved in transcriptomic and protein expression analyses.
| Transcriptomic analyses | ||||||
|---|---|---|---|---|---|---|
| Sacubitril/valsartan n = 36 | Amlodipine n = 34 | Total n = 70 | ||||
| Parameter | Baseline | Post intervention | Baseline | Post intervention | Baseline | Post intervention |
| Age (yrs.) | 52.4 (8.56) | — | 51.6 (9.21) | — | 52.0 (8.83) | — |
| Gender (n) | ||||||
| Male | 28 | — | 25 | — | 53 | — |
| Female | 8 | — | 9 | — | 17 | — |
| Weight (kg) | 100 (18.2) | 101 (19.0) | 104 (15.8) | 105 (16.4) | 102 (17.1) | 103 (17.8) |
| BMI (kg·(m2)−1) | 32.4 (4.77) | 32.6 (5.03) | 33.6 (4.59) | 33.8 (4.96) | 33.0 (4.69) | 33.2 (5.00) |
| Mean sitting SBP (mm Hg) | 143.2 (13.26) | 122.5 (9.97) | 138.8 (11.61) | 125.5 (12.28) | 141.0 (12.60) | 124.0 (11.17) |
| Mean sitting DBP (mm Hg) | 89.6 (7.79) | 81.9 (8.40) | 90.4 (5.87) | 83.4 (6.19) | 90.0 (6.89) | 82.6 (7.40) |
| Protein expression analyses | ||||||
| Sacubitril/valsartan n = 15 | Amlodipine n = 12 | Total n = 27 | ||||
| Parameter | Baseline | Post intervention | Baseline | Post intervention | Baseline | Post intervention |
| Age (yrs.) | 53.6 (6.92) | — | 54.9 (7.04) | — | 54.2 (6.87) | — |
| Gender (n) | ||||||
| Male | 13 | — | 8 | — | 21 | — |
| Female | 2 | — | 4 | — | 6 | — |
| Weight (kg) | 108 (19.2) | 109 (19.8) | 102 (14.4) | 103 (15.1) | 105 (17.1) | 106 (17.8) |
| BMI (kg·(m2)−1) | 34.3 (5.89) | 34.7 (6.05) | 33.1 (3.93) | 33.6 (4.18) | 33.8 (5.06) | 34.2 (5.24) |
| Mean sitting SBP (mm Hg) | 147.2 (10.62) | 127.9 (11.72) | 137.8 (12.59) | 125.9 (13.37) | 143.0 (12.27) | 127.0 (12.27) |
| Mean sitting DBP (mm Hg) | 92.0 (6.10) | 68.3 (10.38) | 87.5 (5.63) | 66.7 (8.81) | 90.0 (6.22) | 67.6 (9.57) |
Data are expressed as mean (SD).