Fig. 2. 2-APB sensitizes BZM cytotoxicity in a panel of cancer cells.

a Chemical structure of 2-Aminoethoxydiphenylborane (2-APB). b 2-APB potentiated the cytotoxic effect of BZM in a panel of cancer cells as indicated. Data are IC₅₀ mean (n = 3) ± S.D. c, d 2-APB enhanced BZM-mediated cytotoxicity in H1975 and A549 NSCLC cell lines, respectively. Cells were co-treated with BZM and 2-APB for 48 h following 2-APB pre-treatment for 2 h as indicated. Data represent the percentages of cell death analyzed by LIVE/DEAD cells analysis (mean ± S.D., n = 3). *P < 0.05, ***P ≤ 0.001 compared to control (untreated). ^#P < 0.05, ^##P ≤ 0.01 compared to single BZM treatment, one-way ANOVA analysis