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. 2018 Mar 2;9(3):361. doi: 10.1038/s41419-018-0397-0

Fig. 8. Simultaneous treatment of 2-APB and BZM decreases the lung metastasis burden in LLC-1 bearing C57BL/6 mouse model.

Fig. 8

a BZM and 2-APB [2 mg/kg/day] co-treatment decreased the lung metastasis frequency. The bar chart represents the number of mice that survived in each group. Number of mice with lung metastatic lesions (black area) and mice without metastatic lesion (gray area) are shown. *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001, Chi-square test. b, c BZM and 2-APB [2 mg/kg/day] combination reduced the metastatic burden area. The percentage of metastatic burden area is displayed in b. Each dot represents one mouse. Data represent mean ± SEM. *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001, Mann–Whitney t-test. Representative H&E stained lung sections images with metastatic lesions are shown in c. Areas of metastatic lesions are shown with arrows, and infiltrating metastatic cells are detailed at higher magnification. Scale bar = 1 mm (×2.5), scale bar = 100 µm (×10), and scale bar = 20 µm (×40)