Fig. 1.

Genetic correlations between the 12 neuroticism items. Genetic correlations between the 12 neuroticism items within both samples (sample 1 is presented in the upper triangle and sample 2 in the bottom triangle). The genetic correlations of the same items measured in both samples are presented on the diagonal. All reported genetic correlations, computed with bivariate LD score regression, are significantly different from zero after Bonferroni correction (P < 2.22 × 10⁻⁴). For the genetic correlations between the same items (diagonal) all 95% confidence intervals included 1, emphasizing concordance in genetic signal across samples. For all other, cross-phenotype genetic correlations, none of the 95% confidence intervals included 1, indicating that all genetic correlations deviated from unity (Supplementary Data 2). See Supplementary Table 1 for a description of the item labels