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. 2018 Feb 26;9:60. doi: 10.3389/fgene.2018.00060

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Copyright © 2018 Haaland, Lie, Romanowska, Gjerdevik, Gjessing and Jugessur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationships between cleft lip, vitamins and ESRRG, visualized as a heterogenic network, where each relationship evidenced in public databases is depicted as an arrow connecting two nodes. Different types of nodes (e.g., genes, diseases, etc.) are connected by different types of relationships (e.g., regulation, interaction, etc.). The nodes and arrows are colored according to the legend at the top of the figure. The thickness of the “DOWNREGULATES_AdG” arrow is less than that of “UPREGULATES_AuG,” and similarly for “DOWNREGULATES_CdG” and “UPREGULATES_CuG.” The numbers on the two latter arrows show the Z-score, which is a measure for the strength of the influence. The figure was generated using the Hetionet network (see the Materials and Methods section for details).