Table 6.
Stratified analyses of the top three SNPs in ESRRG.
| SNP namea | Stratum | RR (95% CI)b | p-value | Frequency |
|---|---|---|---|---|
| rs1339221 | All (child effect) | 0.94 (0.84–1.04) | 0.22 | 0.40 |
| No vitamin use | 1.17 (1.03–1.33) | 0.016 | 0.38 | |
| Vitamin use | 0.66 (0.56–0.78) | 5 × 10−7 | 0.43 | |
| Across strata | 0.56 (0.45–0.69) | 6 × 10−8 | – | |
| rs11117745 | All (child effect) | 0.96 (0.87–1.06) | 0.41 | 0.46 |
| No vitamin use | 1.19 (1.05–1.35) | 0.0064 | 0.46 | |
| Vitamin use | 0.68 (0.58–0.80) | 2 × 10−6 | 0.46 | |
| Across strata | 0.57 (0.46–0.70) | 7 × 10−8 | – | |
| rs2099557 | All (child effect) | 0.96 (0.87–1.06) | 0.40 | 0.40 |
| No vitamin use | 1.15 (1.01–1.31) | 0.031 | 0.37 | |
| Vitamin use | 0.71 (0.61–0.84) | 5 × 10−5 | 0.44 | |
| Across strata | 0.62 (0.50–0.76) | 5 × 10−6 | – |
a
All three SNPs are located within chromosomal region 1q41 according to the 1000 Genomes browser (https://www.ncbi.nlm.nih.gov/variation/tools/1000genomes/).
b
Relative risk (RR) for the overall child effect, and effects within each stratum of vitamin use. Across strata, an effect is measured as the ratio of the RRs (i.e., RRR) for vitamin use and no vitamin use.