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. 2018 Mar 2;9:900. doi: 10.1038/s41467-018-03271-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — CryoEM reconstruction and model of human NBCe1. a In all, 3.9-Å cryoEM densities of the NBCe1 dimer showing side (left) and top (right) views. Individual monomers are colored differently. The transparent gray density represents the amphipol belt. The corresponding 2D class averages are shown in the insets. b Ribbon model (side and top views) of the NBCe1 dimer. c Topology of NBCe1. TMs 1, 2, 4, 8, 9, 11 (green cylinders) together with TM3 (pink) and TM10 (yellow) belong to the core domain. TMs 5, 6, 7, 12, 13, and 14 (orange cylinders) form the gate domain. Helices 1–5 (H1–5) are marked blue. Dotted gray lines represent unmodeled regions. d Three-dimensional (3D) model of the NBCe1 dimer. TMs 1–14 and helices H1-5 are shown as cylinders