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. 2018 Mar 2;9:900. doi: 10.1038/s41467-018-03271-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Ion accessibility pathway of NBCe1. The ion accessibility pathway (a, cyan mesh) and the pore radius value along the pathway (b). c Selected residues (Phe443, Leu446, Asp555, and Lys559) forming the pathway whose substitution significantly alters NBCe1 function^25–28. Lys559 is known to bind to DIDS²⁷, which inhibits NBCe1 function likely via blocking the ion accessibility pathway and/or the conformational changes during the transport cycle