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. 2018 Mar 2;8:3929. doi: 10.1038/s41598-018-22054-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The metformin gel formulation modulates the ERK1/2 MAP kinase phosphorylation state in mice tumors. (A) Representative Western blots of extracts from MDA-MB-231 tumors developed in untreated control mice (CTR), in mice treated with metformin aqueous solution (MH Sol) or metformin-loaded gel (MH Gel), using the antibody against phospho-ERK1/2. Blots were stripped and reprobed with anti-α-tubulin antibody to normalize for differences in protein loading. (B) Densitometric analysis of Western blots performed in MDA-MB-231 tumors (n = 7). Values are reported as the means ± S.E.M. of densitometric measurement of the immunoreactive bands (ANOVA with Dunnett’s post-hoc test: n.s. = not significant, *p < 0.05).