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. 2018 Mar 2;8:3957. doi: 10.1038/s41598-018-22392-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the dose-effect relationship for the three antibiotics. (a–c) PCA plots of the difference spectra (previously defined in text and in Fig. 2) for single bacterial cells of susceptible strain (EC1) incubated for 2 hours with (a) gentamicin (382 spectra), (b) ciprofloxacin (345 spectra) and (c) amoxicillin (418 spectra) at different concentrations (two to four independent experiments per concentration and antibiotic in most cases), with 50%-confidence ellipses plotted for each concentration. (d–f) Box plots of the distributions of the PC1 scores for the different antibiotic concentrations (indicating the correspondence between colors and concentrations). Vertical black lines show the reference MICs.