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. 2018 Mar 2;8:3904. doi: 10.1038/s41598-018-22226-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Map of the phosphoinositide pathway. Red arrows represent fluxes of phosphorylation and blue arrows fluxes of hydrolysis. For each flux, the name (v_i→j) and the group of enzymes that catalysed the reaction are shown. Black arrows represent influxes and effluxes of material entering and leaving the system. SIOSS is a group of phosphatases, consisting of SYNJ 1/2, INPP5 B/J/E, OCRL1, SAC2 and SKIP. PI4K + PIP5KI + DVL denotes a complex formed by the three proteins. Proteins separated by commas catalyzed the same reaction. SYNJ: Synaptojanins; INPP5: Inositol polyphosphate 5-phosphatases; OCRL1: Lowe Oculocerebrorenal Syndrome Protein; SAC2: Suppressor of actin ;SKIP: Skeletal muscle and kidney enriched inositol polyphosphate phosphatase.