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. 2018 Mar 2;8:3904. doi: 10.1038/s41598-018-22226-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PI(3,4,5)P₃ is sensitive to PTEN when v_345→34 is slow. A decrease in PTEN is sufficient to increase the levels of PI(3,4,5)P₃ and change the membrane configuration form apical (low PI(3,4,5)P₃) to basolateral (high PI(3,4,5)P₃). A fast v_345→34 will decrease PI(3,4,5)P₃ and make the membrane much less sensitive to a PTEN change. A PTEN knockdown of 98.33% does not alter the amount of PI(4,5)P₂ in either fast or slow v_345→34 conditions. Fast v_345→34 increases the levels of PI(3,4)P₂ and makes the levels of this lipid dependent on the PI(3,4,5)P₃ pool. Slow v_345→34 is modelled as γ_345→34 = 1e11 and f_345→34 = 0.9982. Fast v_345→34 is modelled as γ_345→34 = 6e13 and f_345→34 = 0.9998. The graph was created in R⁴² and the x axis labels were added with PowerPoint.