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. 2018 Mar 2;8:3904. doi: 10.1038/s41598-018-22226-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predicted changes in PI(4,5)P₂ and PI(3,4)P₂ levels as a consequence of siRNA knockdown assays. Each kinase is inactivated, one at the time, and phosphatases are upregulated. The protein complex catalysing v_0→45 is composed of PIP5KI and PI4K; therefore, when one of these enzymes is knocked out, the complex should be also knocked out. There is also the possibility of knocking out only the complex. Enzymes are coloured according to the classification in the siRNA screens: enzymes activating ENaC are marked red, those inhibiting ENaC are marked green and those exhibiting both effects are marked black. The graph was created in R⁴² and the x axis labels were added with PowerPoint.