Table 2.

Summary of drugs screened

Number refers to a drug’s DrugBank number. Cumulative aging effect is the summed strength of the life extension effects from the GenAge database. This provides an estimate of the “maximum average lifespan change” for each gene as  % effect on lifespan. For example, the C. elegans let-363 gene extends worm lifespan by about 150%. A rotifer target mapped to this gene will receive an aging effect of 150. The Cumulative aging effect for a drug is the sum of all of these effects for all putative rotifer protein targets. Optimal concentration is the experimentally determined drug concentration that produced significantly longer lifespan or healthspan. Purple highlighting—enhanced survival in primary screen, black highlighting—enhanced survival in secondary screen, green highlighting—enhanced survival in primary and secondary screens and life table experiments