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. 2018 Mar 2;8:3907. doi: 10.1038/s41598-018-22326-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Canonical pathway and network analysis by IPA. The 13 enriched proteins in MSC-PLT were analysed through the use of Ingenuity Pathway Analysis (IPA, QIAGEN INC., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis). (a) Significantly altered canonical pathways associated with the enriched surface proteins in MSC-PLT. The canonical pathways included in this analysis are shown in the x-axis of the bar chart. The y-axis indicates the statistical significance calculated using the right-tailed Fisher exact test. (b) Graphical representation of the top ranked network, related to inflammatory responses, with a score of 28, as nodes (molecules) and edges (biological relationship between the different molecules). Red nodes represent the investigated enriched proteins involved in this network. Meanings of node shapes and edges are indicated in the legend within the figure.