Table 2.
Association of significant SNPs with obesity and BMI.
| OBESITY | ZBMI | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| STAGE1 | STAGE 2 | META-ANALYSIS | STAGE 1 | STAGE 2 | META-ANALYSIS | |||||||||||
| SNP (RA/AA) Gene | RAF OW/OB, NW | OR (95%CI) | P | RAF OW/OB, NW | OR (95%CI) | P | OR | P | HetPVal | β(SE) | P | β(SE) | P | β(SE) | P | HetPVal |
| rs6598860(A/G); ARID1A | 0.31,0.24 | 1.37 (1.36–1.37) | 7.8 × 10–4 | 0.29, 0.25 | 1.19 (1.01–1.4) | 0.04 | 1.27 (1.14–1.39) | 1.58 × 10–4 | 0.26 | 0.17 (0.05) | 2.2 × 10−4 | 0.09 (0.03) | 0.01 | 0.12 (0.03) | 1.16 × 10–5 | 0.18 |
| rs4589135 (G/A); ARID1A | 0.43, 0.35 | 1.41 (1.40–1.42) | 1.2 × 10–4 | 0.41, 0.38 | 1.11 (0.96–1.28) | 0.15 | 1.22 (1.08–1.41) | 3.72 × 10–4 | 0.04 | 0.15 (0.04) | 6.0 × 10–4 | 0.08 (0.03) | 0.01 | 0.1 (0.02) | 3.57 × 10–5 | 0.20 |
| rs3804562 (C/T); KAT2B | 0.57, 0.53 | 1.18 (1.17–1.18) | 0.04 | 0.59, 0.55 | 1.14 (0.99–1.32) | 0.08 | 1.15 (1.03–1.32) | 8.93 × 10–3 | 0.76 | 0.11 (0.04) | 7.37 × 10−3 | 0.11 (0.02) | 6.20 × 10–4 | 0.11 (0.02) | 1.35 × 10–4 | 0.86 |
RA = Risk Allele, AA = Alternate Allele, RAF = Risk allele frequency, OW/OW = Overweight/obese individuals, HetPVal = Heterogeneity p value for effect of the SNP in 1st phase and 2nd phase of individuals, Meta-analysis was performed using inverse variance model using fixed effect model using METAL. The OR and beta value presented here are with respect to risk alleles.