Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 2;9(3):349. doi: 10.1038/s41419-018-0387-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a The correlation between the two methods used for CML samples analysis. On x axis are reported the DNA values, while y axis represents the mRNA values. The dashed line is the equality line (X = Y). If there was no or little differences between DNA and RNA measures, the values should have followed the equality line. Our results are clearly not correlated. b The agreement between DNA and RNA values. The area comprised between the two dashed lines represents the 95% confidence interval of DNA values (not null) after 9 months of therapy. Dots represents the mRNA values coupled to DNA ones. Only 56% of mRNA values falls within the DNA confidence interval, but the 89% of measures outside this confidence interval are undetectable mRNA values. c The correlation between DNA and RNA values over time. On the x axis is the time (expressed in months), while on the y axis is the correlation (ρ) value. We observe a decrease in correlation between 100 and 200 days of therapy, which correspond to the decay of cells’ number under 1%. d The conditionate correlation vs. a threshold value. On x axis is the threshold value, while y axis is the correlation (ρ) value. The solid line represents the DNA threshold, while the dashed line represents the mRNA threshold. When we choose DNA as a threshold and we consider undetectable values, DNA and mRNA showed 100% correspondence; but we obtained a very low correlation in all the other follow-ups