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. 2018 Mar 2;8:3950. doi: 10.1038/s41598-018-22278-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lym-miR-137 is required for LTM formation. (a) Blocking of Lym-miR-137 impairs LTM after single trial conditioning in vivo (ANOVA, p < 0.001; Tukey’s tests, INH versus C1 and C2, p < 0.05). Animals (n = 20 per group) were trained 48 h after injection with either the Ls-miR-137 inhibitor (INH) or Invivofectamine only (C1) or miRNA inhibitor negative control (C2). All snails were tested for feeding response to the CS (conditioned response) at 24 h after training. (b) Real-time RT-PCR shows that blocking of Lym-miR-137 (INH) causes up-regulation of Lym-CREB2 mRNA (n = 20 sets of ‘learning ganglia’ per group). All data in this figure are shown as means ± SEM.