Figure 1.

Lymphocyte Counts in Patients Treated with MSCs

Numbers of T cells (CD3⁺, CD4⁺, CD8⁺), NK cells (CD16⁺CD56⁺), and B cells (CD19⁺) in samples collected from patients before the MSC treatment (day 0) and approximately 1 week and 1 month after the first MSC dose are shown. The shaded area represents the current reference interval (range of cell numbers) for a healthy population. (A) Individual lymphocyte numbers in each patient, with mean values and 95% confidence intervals. The numbers of CD3⁺, CD4⁺, and CD19⁺ lymphocytes were very low throughout the follow-up period. (B) Lymphocyte numbers in patients grouped according to the day 28 response to MSCs. Cell numbers are shown as a whisker plot showing the mean value and range. The Kruskal-Wallis test was used to calculate statistical significance. There was no statistically significant difference between the lymphocyte numbers of responding (n = 4) and non-responding (n = 7) patients or between different sample collection time points.