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. 2018 Feb 9;115(9):2216–2221. doi: 10.1073/pnas.1711356115

Fig. 5.

Fig. 5.

Antibody blockade of CXCR3, the common receptor for chemokines CXCL9-11, reduces the influx of CD4+ and CD8+ T cells to C. trachomatis-infected upper genital tracts and ameliorates pathology, but does not affect bacterial burden. Ct D-infected mice were treated with anti-CXCR3 monoclonal antibody or matching isotype control (IgG) and assessed at day 8 postinfection. (A) Quantification by flow cytometry of each indicated cell type in the upper genital tract. CD8+ T cells, **P = 0.0027. CD4+ T cells, ***P = 0.0005. (B) Upper genital tract pathology scores, *P = 0.0344. (C) Bacterial burden in the upper genital tract, P = 0.92. N.S., not significant. (D) Representative H&E-stained sections of Ct D-infected uteri treated with anti-CXCR3 vs. isotype control. *, uterine lumen, where cellular infiltration is ameliorated by anti-CXCR3 treatment.