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. 2018 Feb 12;115(9):2108–2113. doi: 10.1073/pnas.1721783115

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Fig. 4. — Proposed StCopB Cu⁺-binding site. (A) Close-up view of potential Cu⁺-binding site in the StCopB homology model. Residues that may be important in Cu⁺ binding and are absolutely conserved among CopBs include Met186 (TM1), Met187 (TM1), Met224 (TM2), and Cys404 (TM4). (B) Sequence alignment of the TM domains of human ATP7A, L. pneumophila CopA (LpCopA), E. hirae CopB (EhCopB), A. aeolicus copper transporter (AaCtrA3), A. fulgidus CopB (AfCopB), Methanosarcina acetivorans CopB (MaCopB), S. thermophilus CopB (StCopB), T. thermophilus CopB (TtCopB), and Nostoc sp. CopB (NsCopB) showing absolutely conserved residues (blue) among CopAs and CopBs. The residues absolutely conserved among CopBs are also highlighted (*).