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. 2018 Feb 26;9:96. doi: 10.3389/fneur.2018.00096

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Copyright © 2018 Xiao, Li, Chen, Zuo, Rashid, He, Feng, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental design and groups. There are no significant differences of mortality rate (MR) among different surgical brain injury (SBI) groups (A–D). In experiment 3 (C), each surgery group divided into two subgroups: one for western blot (the sham subgroup share with experiment 1) and the other for immunohistochemistry. It was recombinant milk fat globule-EGF factor-8 (rhMFGE8) pretreatment group (rhM8-pre) that rhMFGE8 was injected by i.c.v. at 10 min before SBI, and rhMFGE8 posttreatment group (rhM8-post) that rhMFGE8 was injected by i.c.v. at 6 h after SBI.