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. 2018 Feb 26;9:96. doi: 10.3389/fneur.2018.00096

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Copyright © 2018 Xiao, Li, Chen, Zuo, Rashid, He, Feng, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The different effects between recombinant milk fat globule-EGF factor-8 (rhMFGE8) pretreatment (rhM8-pre) and rhMFGE8 posttreatment (rhM8-post) on brain edema at 24 and 72 h. (A,B) rhM8-pre significantly reduced brain water content in right (ipsilateral) frontal lobes at 24 and 72 h. However, the decreasing of brain water content in rhM8-post was not significant. n = 6 for each group. ^#P < 0.05 vs. sham group, ^##P < 0.01 vs. sham group, ^&P < 0.05 vs. surgical brain injury (SBI) group, and ^&&P < 0.01 vs. SBI group.