Figure 2.

Osteopontin (OPN) upregulates CCR1 and CXCR6 expression in hepatocellular carcinoma cells. A, Heat map of a partial list of mRNA with chemokine receptors expression patterns that correlated with OPN overexpression in hepatocellular carcinoma (HCC) cells. SMMC7721, HepG2 and Hep3B cells were stably transfected with lentiviral (LV)‐OPN, and a quantitative PCR array analysis was carried out to determine the expression profile based a panel of chemokine receptors. B, HCC cells transfected with LV‐OPN vs those transfected with LV‐control. C, HCC cells were stably transfected with LV‐OPN or control. CCR1 and CXCR6 expression was detected by western blot