Table 1.
Univariate and multivariate analysis of factors associated with overall survival and disease‐free survival in hepatocellular carcinoma patients
| Variables | Overall survival | Disease‐free survival | ||||
|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||
| P | HR (95% CI) | P | P | HR (95% CI) | P | |
| Sex (female vs male) | .311 | NA | .784 | NA | ||
| Age, (y) (≤50 vs >50) | .371 | NA | .256 | NA | ||
| HBsAg (negative vs positive) | .588 | NA | .468 | NA | ||
| HCV Ab (negative vs positive) | .600 | NA | .515 | NA | ||
| ALT,U/L (>75 vs ≤75) | .211 | NA | .491 | NA | ||
| GGT,U/L (>54 vs ≤54) | .006** | .181 | .089 | NA | ||
| AFP, ng/mL (>20 vs ≤20) | .08 | NA | .066 | NA | ||
| Tumor size, cm (>5 vs ≤5) | <.001** | 2.639 (1.266‐5.502) | .010** | <.001** | 1.859 (1.061‐3.255) | .030** |
| Tumor number (multiple vs single) | <.001** | .543 | .536 | NA | ||
| Tumor differentiation (III + IV vs I + II) | .243 | NA | .726 | NA | ||
| OPN (high vs low) | <.001** | 2.896 (1.329‐6.315) | .007** | <.001** | 3.233 (1.796‐5.821) | <.001** |
| CCR1 (high vs low) | <.001** | 2.015 (1.037‐3.914) | .039** | <.001** | .143 | |
| Combination OPN and CCR1 | ||||||
| Double high vs double low | <.001** | 5.585 (2.480‐12.577) | <.001** | <.001** | 4.146 (2.093‐8.212) | <.001** |
| Others vs double low | .016** | .062 | .001** | 2.750 (1.348‐5.611) | .005** | |
| Double high vs others | .012** | 2.414 (1.189‐4.905) | .015** | .131 | .182 | |
AFP, α‐fetoprotein; ALT, alanine transaminase; anti‐HCV Ab, anti‐hepatitis C virus antibody; CI, confidence interval; HBsAg, hepatitis B surface antigen; GGT, gamma‐glutamyl transpeptidase; HR, hazard ratio; NA, not adopt.
Univariate analysis, Cox proportional hazards regression model. **P < .05.