Table 2.
Independent factor | Univariate analysis | P‐value | Multivariate analysis | P‐value | ||
---|---|---|---|---|---|---|
Hazard ratio | 95% CI | Hazard ratio | 95% CI | |||
Depth of tumor invasion | ||||||
T1‐T2/T3‐T4 | 42.15 | 9.12‐748.54 | <.0001 | 5.98 | 0.91‐117.89 | .0640 |
Lymph node metastasis | ||||||
Negative/positive | 4.20 | 2.14‐8.86 | <.0001 | 1.53 | 0.71‐3.49 | .2810 |
Distant metastasis | ||||||
Negative/positive | 51.50 | 19.64‐177.57 | <.0001 | 15.60 | 5.10‐63.56 | <.0001 |
Serum CEA level | ||||||
Negative/positive | 6.96 | 3.56‐13.46 | <.0001 | 2.42 | 1.15‐5.10 | .0200 |
Serum CA19‐9 level | ||||||
Negative/positive | 6.16 | 2.95‐12.44 | <.0001 | 1.06 | 0.51‐2.26 | .8810 |
PD‐L1 expression | ||||||
Low/high | 4.64 | 2.23‐10.88 | <.0001 | 2.60 | 1.13‐6.63 | .0240 |
CA19‐9, carbohydrate antigen 19‐9; CEA, carcinoembryonic antigen; CI, confidence interval; T1, invasion of lamina propria or submucosa; T2, invasion of muscularis propria; T3, invasion of subserosa; T4, penetration of serosa or invasion of adjacent structures.