Table 3.

Mean palbociclib plasma C_trough in combination with letrozole in cycles 1 and 2 on day 15

Parameter	Parameter summary statisticsa
	Predose concentration on cycle 1/day 15	Predose concentration on cycle 2/day 15	Predose concentration on day 15, cycles 1 and 2b
N	32	30	38
Ctrough (ng/mL)	89.4 (44)	86.8 (40)	90.1 (42)

C_trough, predose concentration during multiple dosing; N, number of patients evaluated with the steady‐state C_trough.

The calculation required 2 conditions to be met for the steady state C_trough evaluable criteria: (i) C_trough following at least 7 consecutive days of palbociclib 125 mg daily dose without dosing interruption, and (ii) C_trough to have the actual sampling time, which was ≤10% time deviation of the nominal time from 24 h after the last dose on day 14.

^aGeometric mean (geometric % coefficient of variation) for all.

^bGeometric mean of within‐patient mean C_trough on cycles 1 and 2 on day 15.