Figure 4.
Antitumor effect of T‐01 in mice with orthotopic tumors. Human tumor cells (HuH‐7‐Luc, KYN‐2‐Luc and HepG2‐Luc) were implanted in the liver of male athymic mice. Established tumors were inoculated with mock preparation (open circles) or T‐01 (2 × 106 pfu) (filled circles) once on day 0. A, Effect of T‐01 on growth of tumors from HuH‐7‐Luc cells. Tumor growth was determined by measuring the tumor volume 21 d after implantation in the mock‐ and T‐01‐treated groups (upper graph). In the middle panel, blue circles indicate orthotopic tumors in the mock‐treated and T‐01 treated mice (representative images of 5 mice in the 2 groups). Survival of mock‐treated and T‐01‐treated mice with tumors from HuH‐7‐Luc cells (A, lower panel), KYN‐2‐Luc cells (B) and HepG2‐Luc cells (C). Data represent the mean ± SE (n = 10 mice per time point per group). *P < .05 and **P < .01 vs mock treatment