Table 4.
Incidence of treatment-emergent drug-related adverse events by worst grade and Child-Pugh class at start of therapy
| Drug-related adverse events | Child-Pugh A | Child-Pugh B | Child-Pugh C |
|---|---|---|---|
| (n = 246) | (n = 48) | (n = 2) | |
| Any adverse event | 67 (27) | 17 (35) | 0 (0) |
| Cardiac, general | 8 (3.3) | 1 (2.1) | 0 (0) |
| Hypertension | 7 (2.8) | 1 (2.1) | 0 (0) |
| Hypotension | 2 (0.8) | 0 (0) | 0 (0) |
| Constitutional symptoms | 2 (0.8) | 0 (0) | 0 (0) |
| Fatigue | 1 (0.4) | 0 (0) | 0 (0) |
| Fever | 1 (0.4) | 0 (0) | 0 (0) |
| Dermatology/skin | 58 (24) | 12 (25) | 0 (0) |
| Alopecia | 6 (2.4) | 2 (4.2) | 0 (0) |
| Hand-foot skin reaction | 51 (21) | 7 (15) | 0 (0) |
| Rash/desquamation | 8 (3.3) | 3 (6.3) | 0 (0) |
| Ulceration | 0 (0) | 0 (0) | 0 (0) |
| Gastrointestinal | 25 (10) | 8 (17) | 0 (0) |
| Diarrhea | 25 (10) | 7 (15) | 0 (0) |
| Nausea | 0 (0) | 1 (2.1) | 0 (0) |
Data are presented as count (percentage). Percentages are presented to 2 significant figures