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. 2018 Mar 2;12:25. doi: 10.1186/s12918-018-0557-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Escher map of arabinogalactan-peptidoglycan complex biosynthesis with known resistance-conferring genes mapped. The gene-antibiotic relation is indicated by the number placed proximal to the gene. The mechanistic effect by the antibiotic is indicated by the blue line. No blue line is shown for mutations in which the gene-antibiotic relation remains unclear (i.g., mshC, drrBC), Escher-usable maps were built for multiple subsystems in iEK1011 (see Additional file 4)