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. Author manuscript; available in PMC: 2018 Mar 3.
Published in final edited form as: Ann Rheum Dis. 2016 Dec 13;76(5):914–922. doi: 10.1136/annrheumdis-2016-210426

Figure 2.

Figure 2

CCR2 deficiency attenuates osteoarthritis in mice. (A) Representative safranin-o stained knee joint sections showing severe cartilage damage (open arrows) and osteophytes (filled arrows) and (B) quantification of cartilage damage in wild-type (WT, n=4) but not Ccr2−/− (n=5) mice 20 weeks after destabilisation of the medial meniscus surgery by a blinded investigator. (C) Representative immunohistochemistry and (D) quantification of F4/80+ (brown) macrophages lining the synovium (red arrows) in WT and Ccr2−/− mice. Symbols denote individual mice, and bars denote the mean of indicated groups in (B) and (D). Scale bars denote 200 μm. *p<0.05 by the Mann-Whitney U test for (B) and by Students t-test ‘ for (D). The presented data are representative of two independent experiments with similar results.