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GGC1 in DPC lacks the expected binding specificity. (A) Chemical-shift perturbations in GGC1 upon addition of GTP. (B) Plot of amide (H/N/CO) and methyl (H/C) CSPs onto a structural model of GGC1. (C,D) GTP and ATP produces very similar CSPs in GGC1, as exemplified with extracts from HNCO spectra (D) and shown as a correlation plot in (C). The inset shows the electrostatic surface of a AAC-derived structural model of GGC1. Equivalent data for AAC3 are shown in Figure S21.
