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Schematic of combined CRISPRi/a screens.
A: Schematic of pooled CRISPRi and CRISPRa screens for drug sensitivity. Other pooled screens can be conducted analogously using the corresponding cell lines and libraries.
B: Comparing knockdown and overexpression data such as those from combined CRISPRi and CRISPRa screens reveals genes with anti-correlated sensitivity phenotypes. These genes are likely to be directly involved in the pathway targeted by the drug.
