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. 2018 Feb 27;9:331. doi: 10.3389/fimmu.2018.00331

Figure 1.

Figure 1

Pretransplant conditioning did not result in a pro-inflammatory environment in the skin at the time of transplantation. (A) In normal skin, HLA class II-expressing cells and also T-cells are present scattered over the whole dermal region. In the epidermal layer, HLA class II-expressing cells were observed sporadically. (B) In skin affected by dermatitis medicamentosa, dermal area count of HLA class II-expressing cells and T-cells is higher compared to normal skin. After non-myeloablative (NMA) conditioning (C) and myeloablative (MA) conditioning (D), the presence of HLA class II-expressing cells and T-cells at the time of allogeneic stem cell transplantation (alloSCT) resembled the situation in normal skin. Dermal area counts with median were calculated for HLA class II-expressing cells (E) and CD3 T-cells (F) in skin biopsies of normal skin, skin at the time of alloSCT after NMA and MA conditioning, and skin affected by dermatitis medicamentosa. A significant difference was detected regarding HLA class II-expressing cells between normal skin and skin affected by dermatitis medicamentosa (Kruskal–Wallis test p = 0.019, post hoc Mann–Whitney U-test p = 0.016). White line demarks the border between dermis and epidermis.