Figure 2.

The different chromatin organization necessitates distinct modifications to facilitate transcription: Chromatin organization at Cga and Lhb regulatory regions are shown in their active states, with DNA and histone modifications as noted. *S28p was examined only at the proximal region of Cga; **at the downstream nucleosomes, only H3K36me3 and H2K120Bub were assessed; ^#histone acetylation and phosphorylation are inferred but were not measured directly on the Lhb promoter. Furthermore, the nucleosomal density on the Lhb proximal promoter precluded precise mapping of H3K4me3. Dotted lines represent DNA packaged into additional nucleosomes that are not shown, and the blue arrows represent nucleosome mobility due to H2A.Z incorporation. Further details can be found in the text.