Table 2.
Reported miRNA pathways modulators present in bioactive and diversity sets.
Compound | Family | References | Structure | Primary HTS activity | Positive assay type | Primary HTS activity >cut-off | Dose response assay | Dose response assay type | Note |
---|---|---|---|---|---|---|---|---|---|
6-Hydroxy-DL-DOPA | Dopamines | Shum et al., 2012 | ![]() |
Yes | miR-30-B | Yes | Confirmed | Weak in let-7-B 3T3 only | |
Amikacin | Antibiotics | Bose et al., 2013 | ![]() |
No | Not active | No | – | – | |
Apigenin | Flavones | Shibata et al., 2014 | ![]() |
Yes | Bulged reporters | No | – | – | Flavones had many hits |
Aurintricarboxylic acid (ATA) | Tan et al., 2012 | ![]() |
Yes | let-7-P 3T3 | No | – | – | ||
Daunorubicin | Anthracyclines | Maiti et al., 2012 | ![]() |
Yes | let-7-P Hela | No | – | – | Idarubicin was a hit |
Deoxycorticosterone | Corticoids | Shum et al., 2012 | ![]() |
Yes | let-7-P 3T3 activator | No | – | – | Cortisol was a hit |
Doxorubicin | Anthracyclines | Maiti et al., 2012 | ![]() |
Yes | let-7-P Hela | No | – | – | Idarubicin was a hit |
Enoxacin | Shan et al., 2008; Melo et al., 2011 | ![]() |
No | Not active | No | – | – | ||
Epigallocatechin-3-monogallate | Asada et al., 2016 | ![]() |
No | Not active | No | – | – | ||
Ethidium | Maiti et al., 2012 | ![]() |
No | Not active | No | – | – | ||
Flutamide | Shum et al., 2012 | ![]() |
No | Not active | No | – | – | ||
Kanamycin A | Amtibiotics | Luciferase reporters | ![]() |
No | Not active | No | – | – | |
Neomycin B | Antibiotics | Bose et al., 2013; Tran et al., 2015 | ![]() |
No | Not active | No | – | – | |
Pterostilbene | Stilbens | Hagiwara et al., 2012 | ![]() |
Yes | All reporters | No | – | – | |
Rifampicin | Antibiotics | Takahashi et al., 2014 | ![]() |
Yes | All reporters | No | – | – | |
Streptomycin | Antibiotics | Bose et al., 2012, 2013 | ![]() |
No | Not active | No | – | – | |
Tobramycin | Antibiotics | Bose et al., 2013 | ![]() |
Yes | let-7-P 3T3 activator | No | – | – | |
Trans-resveratrol | Stilbens | Hagiwara et al., 2012 | ![]() |
Yes | let-7-B | No | – | – |