Table 2.

Reported miRNA pathways modulators present in bioactive and diversity sets.

Compound	Family	References	Structure	Primary HTS activity	Positive assay type	Primary HTS activity >cut-off	Dose response assay	Dose response assay type	Note
6-Hydroxy-DL-DOPA	Dopamines	Shum et al., 2012		Yes	miR-30-B	Yes	Confirmed	Weak in let-7-B 3T3 only
Amikacin	Antibiotics	Bose et al., 2013		No	Not active	No	–	–
Apigenin	Flavones	Shibata et al., 2014		Yes	Bulged reporters	No	–	–	Flavones had many hits
Aurintricarboxylic acid (ATA)		Tan et al., 2012		Yes	let-7-P 3T3	No	–	–
Daunorubicin	Anthracyclines	Maiti et al., 2012		Yes	let-7-P Hela	No	–	–	Idarubicin was a hit
Deoxycorticosterone	Corticoids	Shum et al., 2012		Yes	let-7-P 3T3 activator	No	–	–	Cortisol was a hit
Doxorubicin	Anthracyclines	Maiti et al., 2012		Yes	let-7-P Hela	No	–	–	Idarubicin was a hit
Enoxacin		Shan et al., 2008; Melo et al., 2011		No	Not active	No	–	–
Epigallocatechin-3-monogallate		Asada et al., 2016		No	Not active	No	–	–
Ethidium		Maiti et al., 2012		No	Not active	No	–	–
Flutamide		Shum et al., 2012		No	Not active	No	–	–
Kanamycin A	Amtibiotics	Luciferase reporters		No	Not active	No	–	–
Neomycin B	Antibiotics	Bose et al., 2013; Tran et al., 2015		No	Not active	No	–	–
Pterostilbene	Stilbens	Hagiwara et al., 2012		Yes	All reporters	No	–	–
Rifampicin	Antibiotics	Takahashi et al., 2014		Yes	All reporters	No	–	–
Streptomycin	Antibiotics	Bose et al., 2012, 2013		No	Not active	No	–	–
Tobramycin	Antibiotics	Bose et al., 2013		Yes	let-7-P 3T3 activator	No	–	–
Trans-resveratrol	Stilbens	Hagiwara et al., 2012		Yes	let-7-B	No	–	–