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. 2018 Feb 27;9:135. doi: 10.3389/fphar.2018.00135

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Copyright © 2018 Liu, Claret, Zhou and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ingenuity Pathway Analysis (IPA) for Jab1/COPS5 regulation network in cancer. Jab1/COPS5 is a multiple protein and plays an essential role in tumorigenesis. In this case we showed the predicted expression level of other genes in the regulation network in response to increased measured level of let-7 based on the IPA database. The color of each gene represents the corresponding expression level. Light-red means activation and light-blue means inhibition, while red means increased measurement and green means decreased measurement.