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. 2018 Feb 27;9:135. doi: 10.3389/fphar.2018.00135

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Copyright © 2018 Liu, Claret, Zhou and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ingenuity Pathway Analysis for the interaction between Jab1/COPS5 and PD-L1. In this case we showed the predicted expression level of other genes in the regulation network in response to increased measured level of PD-L1 based on the IPA database. The miRNAs in the figure are predicted ones that can target both Jab1/COPS5 and PD-L1, but no demonstration was reported yet. The color of each gene represents the corresponding expression level. Light-red means activation and light-blue means inhibition, while red means increased measurement and green means decreased measurement.