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. 2018 Feb 27;12:96. doi: 10.3389/fnins.2018.00096

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Copyright © 2018 Yin, Li, Liu, Chen, Zhang, Li, He and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of signaling pathway components downstream of PP2A/TTP after SAH. (A,B) PP2A knockdown decreased Garcia test score and increased brain water content 24 h after SAH; these effects were reversed by FTY720. (C) PP2A knockdown abrogated the effects of FTY720 on TTP and Bcl-2 expression and increased the levels of TNF-α, IL-6, and IL-8, and caspase-3 in the ipsilateral cortex 24 h after SAH. Relative intensity of each protein band was normalized to that in the sham group (n = 6 per group). ^*P < 0.05 vs. sham; ^#P < 0.05 vs. SAH+vehicle and SAH + siRNA; ^&P < 0.05 vs. SAH + FTY720.