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. 2018 Feb 27;9:385. doi: 10.3389/fimmu.2018.00385

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Copyright © 2018 Lichtenegger, Rothe, Schnorfeil, Deiser, Krupka, Augsberger, Schlüter, Neitz and Subklewe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 (LAG-3) blockade on proliferation of EBV antigen-specific T cells after stimulation with TLR-3-DCs. non-adherent cell (NACs) of 9 healthy donor (HDs) were cocultured with autologous Epstein–Barr nuclear Ag 3 A peptide FLRGRAYGL (FLR)-pulsed TLR-3-DCs in the presence or absence of α-PD-1 and α-LAG-3 antibody. (A) The percentage of FLR tetramer positive cells within the CD8⁺ T cell population was determined by flow cytometry. Data for fold change to the condition without blocking antibody are presented as box-and-whisker plots, and statistical significance was calculated against a fold change of 1.0. *p < 0.05. (B) PD-1 and LAG-3 expression was determined for FLR tetramer positive CD8⁺ T cells after stimulation with non-pulsed or FLR-pulsed TLR-3-DCs.