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. 2017 Nov 21;26(2):404–419. doi: 10.1016/j.ymthe.2017.11.011

Figure 3.

Figure 3

Abscopal Effects of Local Irradiation Plus the CTGF/E7 DNA Vaccine on Distant Tumors of the Contralateral Leg without Irradiation or Pulmonary Metastatic Tumors

(A) Volumes of distant tumors from the contralateral leg of mice treated with local irradiation on the index tumor of the right hind leg (n = 5 per group). Data are shown as mean ± SD. (B) Volumes of distant tumors from the contralateral leg of mice treated with the CTGF/E7 DNA vaccine alone or combined with local irradiation on the index tumor of the right hind leg (n = 5 per group). Data are shown as mean ± SD. (C) Magnification of the distant tumor volumes from the contralateral leg of mice treated with DNA vaccine combined with local irradiation on the index tumor of the right hind leg (n = 5 per group). Data are shown as mean ± SD. (D) Representative figures of pulmonary metastatic tumors from mice treated with local irradiation on the index tumor of the right hind leg and/or the CTGF/E7 DNA vaccine (n = 5 per group). (E) Bar figure indicating the numbers of pulmonary metastatic tumors in mice treated with local irradiation on the index tumor of the right hind leg and/or the CTGF/E7 DNA vaccine (n = 5 per group). Data are shown as mean ± SD. (F) Survival curves of mice having pulmonary metastatic nodules treated with local irradiation on the index tumor of the right hind leg and/or the CTGF/E7 DNA vaccine (n = 5 per group).