Table 2.
Index | Opium use | ||||
---|---|---|---|---|---|
None | Low dose opium use | High dose opium use | |||
<81 Nokhod-year | P value | ≥81 Nokhod-year | P value | ||
N. of cases (patients) | 37 | 9 | 8 | ||
Person-year | 296,781 | 45,006 | 11,103 | ||
HR (95% CI) (model 1) | Ref. | 1.44 (0.68–3.04) | 0.337 | 4.49 (2.00–1.07) | <0.001 |
HR (95% CI) (model 2) | Ref. | 1.20 (0.55–2.63) | 0.642 | 3.43 (1.44–8.18) | 0.005 |
HR (95% CI) (model 3) | Ref. | 1.16 (0.52–2.55) | 0.718 | 3.13 (1.30–7.61) | 0.011 |
HR (95% CI) (model 4) | Ref. | 1.10 (0.49–2.44) | 0.819 | 2.92 (1.20–7.12) | 0.019 |
COX hazard ratio adjusted for age, sex (model 1); further adjusted for cigarette smoking status (never, ever) and alcohol consumption (never, ever) (model 2); cigarette smoking status was modeled as never, former, or current (model 3); further adjusted for type 2 diabetes mellitus and BMI (model 4).