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. Author manuscript; available in PMC: 2018 Mar 4.
Published in final edited form as: Curr Top Med Chem. 2017;17(32):3425–3443. doi: 10.2174/1568026618666180118154514

Figure 2.

Figure 2

Figure 2

Figure 2

Figure 2

X-ray structure of LFA-1 I-Domain in complex with ICAM-1 (PDB: 1MQ8). (A) ICAM-1 protein forms a homodimer, which interacts with two separate I-domains of LFA-1 at each D-1 domain of ICAM-1. Counter-clockwise quarter-turn on the encircled interface shows (B) the interacting region of LFA-1 I-domain with ICAM-1, also referred to as the MIDAS region (yellow/gold), which overlaps with the region of the LABL peptide sequence (green). (C) Shows the region on LFA-1 interacting with the IEL sequence (purple) from ICAM-1. (D) Maps regions on the ICAM-1 homodimer where IB (cyan) and IE (yellow) peptide sequences are located.