Table 2.
Coronary Physiology and CMR Parameters
| Normal Control Subjects (n = 20) | Patients With Obstructive CAD (n = 28) | Patients With All NOCAD (n = 22) | p Value | |
|---|---|---|---|---|
| CMR parameters | ||||
| LV EDVi, ml/m2 | 75 ± 11 | 78 ± 11 | 77 ± 13 | 0.40 |
| LV ESVi, ml/m2 | 28 ± 8 | 32 ± 12 | 30 ± 12 | 0.26 |
| LV SVi, ml/m2 | 47 ± 6 | 46 ± 10 | 47 ± 12 | 0.91 |
| LV ejection fraction, % | 62 ± 5 | 59 ± 9 | 61 ± 10 | 0.35 |
| LV mass index, g/m2 | 58 ± 10 | 59 ± 11 | 56 ± 13 | 0.25 |
| Mean LV wallthickness, mm | 7.9 ± 0.6 | 7.5 ± 1.5 | 7.4 ± 0.7 | 0.23 |
| MPRI | 2.0 ± 0.3 | 1.2 ± 0.4∗ | 1.6 ± 0.5∗† | <0.001 |
| Rest MBF | 1.1 ± 0.2 | 1.1 ± 0.3 | 1.1 ± 0.2 | 0.80 |
| Stress MBF | 3.0 ± 0.5 | 1.4 ± 0.4∗ | 2.1 ± 0.8∗† | <0.001 |
| LGE, % | 0 ± 0 | 10 ± 5∗ | 0 ± 0† | <0.001 |
| Coronary physiology | ||||
| FFR | – | 0.60 (0.28–0.79) | 0.92 (0.80–1.00) | <0.001 |
| IMR, U | – | 27 ± 15 | 27 ± 14 | 0.91 |
| IMRcorr, U | – | 21 ± 11 | 27 ± 14 | 0.05 |
| Distribution of FFR and IMR | ||||
| Total vessels assessed | – | 60 (71) | 66 (100) | 0.17 |
| FFR <0.8 and IMR ≥25 U | – | 10 (17) | 0 (0) | <0.001 |
| FFR <0.8 and IMR <25 U | – | 20 (33) | 0 (0) | <0.001 |
| FFR ≥0.8 and IMR ≥25 U | – | 11 (18) | 28 (42) | <0.001 |
| FFR ≥0.8 and IMR <25 U | – | 19 (32) | 38 (58) | <0.001 |
Values are mean ± SD, mean (range), or n (%). All p values for CMR parameters were determined by using an analysis of variance with Bonferroni post hoc method. All p values for coronary physiology were determined by using an unpaired Student’s t-test.
EDVi = end-diastolic volume index; ESVi = end-systolic volume index; FFR = fractional flow reserve; IMR = index of microvascular resistance; IMRcorr = Yong formula–corrected IMR; LGE = late gadolinium enhancement; LV = left ventricular; MBF = myocardial blood flow; MPRI = myocardial perfusion reserve index; SVi = stroke volume index; other abbreviations as in Table 1.
∗
p < 0.01 compared with control subjects.
†
p < 0.01 compared with patients with CAD.