Table 4.
Comparison of genotypes between children born from preeclamptic and noncomplicated pregnancies.
| Fetal genotypes and alleles | PE group N = 86 N (%) |
Control group N = 85 N (%) |
p a | pHWEb |
|---|---|---|---|---|
| −1607 1G/2G MMP1 (rs1799750) | ||||
| 1G/1G | 30 (35%) | 12 (14%) | <0.01 | 0.503 |
| 1G/2G | 43 (50%) | 36 (42%) | 0.316 | |
| 2G/2G | 13 (15%) | 37 (44%) | <0.001 | |
| 1G | 103 (60%) | 60 (35%) | <0.0001 | |
| 2G | 69 (40%) | 110 (65%) | ||
|
| ||||
| −1171 5A/6A MMP3 (rs35068180) | ||||
| 5A/5A | 12 (14%) | 17 (20%) | 0.291 | 0.841 |
| 5A/6A | 62 (72%) | 41 (48%) | <0.01 | |
| 6A/6A | 12 (14%) | 27 (32%) | <0.01 | |
| 5A | 86 (50%) | 75 (44%) | 0.276 | |
| 6A | 86 (50%) | 95 (56%) | ||
|
| ||||
| −1562C/T MMP9 (rs3918242) | ||||
| CC | 67 (78%) | 61 (72%) | 0.354 | 0.487 |
| CT | 19 (22%) | 21 (25%) | 0.687 | |
| TT | 0 (0%) | 3 (3%) | 0.240 | |
| C | 153 (89%) | 143 (84%) | 0.190 | |
| T | 19 (11%) | 27 (16%) | ||
|
| ||||
| −735 C/T MMP2 (rs2285053) | ||||
| CC | 66 (77%) | 69 (81%) | 0.477 | 0.857 |
| CT | 18 (21%) | 15 (18%) | 0.586 | |
| TT | 2 (2%) | 1 (1%) | 0.992 | |
| C | 150 (87%) | 153 (90%) | 0.417 | |
| T | 22 (13%) | 17 (10%) | ||
|
| ||||
| −1306 C/T MMP2 (rs243865) | ||||
| CC | 50 (58%) | 48 (56%) | 0.825 | 0.304 |
| CT | 27 (31%) | 34 (40%) | 0.240 | |
| TT | 9 (11%) | 3 (4%) | 0.140 | |
| C | 127 (74%) | 130 (76%) | 0.573 | |
| T | 45 (26%) | 40 (24%) | ||
aFor p value analysis, the chi2 or Yates' corrected chi2 tests were used; bHWE: Hardy–Weinberg equilibrium.