Table 6.
Distribution of genotypes of studied polymorphisms among female and male preeclamptic and control groups.
| Genotypes | Female PE children N = 34 |
Female control children N = 47 |
p a | OR (95% CI) | Male PE children N = 52 |
Male control children N = 38 |
p a | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| −1607 1G/2G MMP1 (rs1799750) | ||||||||
| 1G/1G | 12 (35%) | 5 (10%) | <0.05 | 4.58 (1.43–14.67) | 18 (35%) | 7 (18%) | 0.085 | NSb |
| 1G/2G | 15 (44%) | 21 (45%) | 0.959 | NSb | 28 (54%) | 15 (39%) | 0.176 | NSb |
| 2G/2G | 7 (21%) | 21 (45%) | <0.05 | 0.32 (0.12–0.88) | 6 (12%) | 16 (42%) | <0.01 | 0.18 (0.06–0.52) |
|
| ||||||||
| −1171 5A/6A MMP3 (rs35068180) | ||||||||
| 5A/5A | 4 (12%) | 9 (19%) | 0.557 | NSb | 8 (15%) | 8 (21%) | 0.678 | NSb |
| 5A/6A | 25 (73%) | 26 (55%) | 0.091 | NSb | 37 (71%) | 15 (39%) | <0.01 | 3.78 (1.56–9.16) |
| 6A/6A | 5 (15%) | 12 (26%) | 0.366 | NSb | 7 (13%) | 15 (39%) | <0.01 | 0.24 (0.08–0.67) |
|
| ||||||||
| −1562C/T MMP9 (rs3918242) | ||||||||
| CC | 29 (85%) | 32 (68%) | 0.131 | NSb | 38 (73%) | 29 (76%) | 0.918 | NSb |
| CT | 5 (15%) | 14 (30%) | 0.188 | NSb | 14 (37%) | 7 (18%) | 0.490 | NSb |
| TT | 0 (0%) | 1 (2%) | 0.870 | NSb | 0 (0%) | 2 (5%) | 0.343 | NSb |
|
| ||||||||
| −735 C/T MMP2 (rs2285053) | ||||||||
| CC | 25 (73%) | 35 (74%) | 0.872 | NSb | 41 (79%) | 34 (89%) | 0.294 | NSb |
| CT | 8 (24%) | 11 (23%) | 0.801 | NSb | 10 (19%) | 4 (11%) | 0.406 | NSb |
| TT | 1 (3%) | 1 (2%) | 0.622 | NSb | 1 (2%) | 0 (0%) | 0.874 | NSb |
|
| ||||||||
| −1306 C/T MMP2 (rs243865) | ||||||||
| CC | 25 (73%) | 28 (60%) | 0.189 | NSb | 25 (48%) | 20 (53%) | 0.669 | NSb |
| CT | 8 (24%) | 19 (40%) | 0.107 | NSb | 19 (37%) | 15 (39%) | 0.777 | NSb |
| TT | 1 (3%) | 0 (0%) | 0.870 | NSb | 8 (15%) | 3 (8%) | 0.436 | NSb |
aFor p value analysis, the chi2 or Yates' corrected chi2 tests were used; bNS: not significant.